• Argentatin, Asteraceae (family), Compositae (family), daisies, dandelion, goldenrod, guayule rubber plant, Parthenium argentatum (Gray)., ragweed, sunflower.

• Guayule (Parthenium argentatum) is native to the southwestern United States and may be a natural source of hypoallergenic latex because large quantities of rubber accumulated in its cells lack the latex proteins that cause allergic reactions. Preliminary tests show that guayule latex film may be an effective barrier to virus transmission, even after long-term storage.
• There is currently insufficient evidence available in humans to support the use of guayule for any indication.

• Surgical uses (hypoallergenic latex).

Adults (18 years and older):

• There is no proven safe or effective dose for guayule in adults.

Children (younger than 18 years):

• There is no proven safe or effective dose for guayule in children.

Allergies

• Avoid in individuals with a known allergy or hypersensitivity to guayule (Parthenium argentatum), its constituents, or members of the Asteraceae/Compositae family, such as dandelion, goldenrod, ragweed, sunflower, and daisies.
• Guayule is being pursued as a hypoallergenic source of latex because in laboratory studies, its proteins do not cross-react with antibodies raised against latex proteins in conventional Hevea brasiliensis latex products.

Side Effects and Warnings

• There is insufficient evidence in humans to support the use of guayule for any indication. Use guayule cautiously in patients with compromised hepatic (liver) function or taking agents metabolized by the cytochrome P450 pathways.

Pregnancy and Breastfeeding

• Guayule is not recommended in pregnant or breastfeeding women due to a lack of available scientific evidence.

Interactions with Drugs

• Guayule may interfere with the way the body processes certain drugs using the liver's cytochrome P450 system. As a result, the levels of these drugs may be altered, and may increase/decrease the effects or increase potentially serious adverse reactions. If using any medications, check the package insert and speak with a qualified healthcare professional, including a pharmacist, about possible interactions.
• Constituents from guayule showed cytotoxic effects on cancer cell lines. Although the clinical significance is unknown, caution is advised in patients taking anticancer agents due to unknown combined effects.

Interactions with Herbs and Dietary Supplements

• Guayule may interfere with the way the body processes certain herbs or supplements using the liver's cytochrome P450 system. As a result, the levels of other herbs or supplements may be too high in the blood. It may also alter the effects that other herbs or supplements possibly have on the P450 system, such as chamomile, Echinacea, oregano, and St. John's wort.
• Constituents from guayule showed cytotoxic effects on cancer cell lines. Although the clinical significance is unknown, caution is advised in patients taking anticancer agents due to unknown combined effects.

• This information is based on a systematic review of scientific literature edited and peer-reviewed by contributors to the Natural Standard Research Collaboration (www.naturalstandard.com).

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2. Cornish K, Lytle CD. Viral impermeability of hypoallergenic, low protein, guayule latex films. J.Biomed.Mater.Res. 12-5-1999;47(3):434-437.
3. Pan Z, Durst F, Werck-Reichhart D, et al. The major protein of guayule rubber particles is a cytochrome P450. Characterization based on cDNA cloning and spectroscopic analysis of the solubilized enzyme and its reaction products. J.Biol.Chem. 4-14-1995;270(15):8487-8494.
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